KMID : 0356820080240020162
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Korean Journal of Head & Neck Oncology 2008 Volume.24 No. 2 p.162 ~ p.168
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Treatment Outcome after Induction Chemotherapy Followed by Radiation Therapy in Locally Advanced Hypopharyngeal Cancer
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Song Si-Yeol
Ahn Seung-Do Kim Sang-Yoon Nam Soon-Yuhl Kim Sung-Bae Choi Eun-Kyung Lee Sang-Wook Kim Jong-Hoon Je Hyoung-Uk
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Abstract
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Purpose:To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer
Methods and Materials£º From August 1990 to December 2003, forty patients who were treated with induction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range£º40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median£º70.8Gy).
Results: Median follow-up time was 39.4 months(range£º8-115 months). Treatment failures were observed in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients.
Conclusion:Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.
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KEYWORD
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Hypopharyngeal Cancer, Induction Chemotherapy, Radiation Therapy, Larynx Preservation
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